Icyatsi gishya gitanga imiti 99% Isuku Metallothionein Ifu Yibikoresho Metallothionein Mt Inkwavu Umwijima Zinc Metallothionein
Ibisobanuro ku bicuruzwa
Metallothionein ni poroteyine yuburemere buke ifite ubushobozi bwo guhuza ibyuma hamwe nubwinshi bwo kwinjiza. [1] Peptide ngufi ikungahaye kuri sisitemu ifitanye isano ryinshi ryibyuma bitandukanye biremereye. Ni poroteyine ifite uburemere buke bwa molekile kandi irimo ibintu byinshi cyane bya sisitine n'ibisigara. Ibyuma byahujwe cyane cyane ni kadmium, umuringa na zinc, biboneka cyane mu binyabuzima bitandukanye kuva mikorobe kugeza ku bantu, kandi imiterere yabyo irabungabunzwe cyane.
COA
| INGINGO | STANDARD | IGISUBIZO CY'IKIZAMINI |
| Suzuma | 98% min Metallothionein | Guhuza |
| Ibara | Ifu yera | Guhuza |
| Impumuro | Nta mpumuro idasanzwe | Guhuza |
| Ingano ya Particle | 100% batsinze 80mesh | Guhuza |
| Gutakaza kumisha | ≤5.0% | 2.35% |
| Ibisigisigi | ≤1.0% | Guhuza |
| Icyuma kiremereye | ≤10.0ppm | 7ppm |
| As | ≤2.0ppm | Guhuza |
| Pb | ≤2.0ppm | Guhuza |
| Ibisigisigi byica udukoko | Ibibi | Ibibi |
| Umubare wuzuye | ≤100cfu / g | Guhuza |
| Umusemburo & Mold | ≤100cfu / g | Guhuza |
| E.Coli | Ibibi | Ibibi |
| Salmonella | Ibibi | Ibibi |
| Umwanzuro | Guhuza nibisobanuro | |
| Ububiko | Bibitswe muri Cool & Ahantu humye, Komeza wirinde urumuri rukomeye nubushyuhe | |
| Ubuzima bwa Shelf | Imyaka 2 iyo ibitswe neza | |
Imikorere
MT ni poroteyine ihuza ibyuma bikungahaye kuri sisitemu. Itsinda ryayo rya sulfhydryl rirashobora gushonga cyane ibyuma byuburozi no kubisohora mumubiri, bityo bikageraho. [4] MT ifitanye isano na metabolism yibyuma. Mu nyama zose z’inyamabere, MT-1 na MT-2 bigaragarira hamwe. MT-3 ni umwe mu bagize ubwonko muri uyu muryango. Irashobora guhuza zinc n'umuringa kandi ifite ibikorwa byingenzi bya neurophysiologique na neuromodulation. Ubushakashatsi ku binyabuzima byinshi byo mu mazi bwerekanye ko MT igira uruhare runini mugutunganya ibyuma byibanze, kandi ikagira ingaruka zo kubuza no kwangiza ibintu bitari shingiro byibyuma. MT irashobora kugabanya neza uburozi bwibyuma biremereye mumubiri muguhuza nibyuma biremereye, kandi kuri ubu niwo muti mwiza wa biologiya chelating antidote mubikorwa byubuvuzi.
Kurengera ibidukikije
Ukoresheje ibiranga guhuza MT hamwe nicyuma, birashoboka kubyara cyangwa gukoresha ingengabihe ya geneti kugirango ushyireho uburyo bwo kwerekana imiterere ya MT mu kurwanya umwanda uremereye. Nk’uko amakuru abitangaza, itabi ryandujwe n’imisemburo ya MT irashobora kongera cyane iyinjizwa rya cu2 mu butaka bwanduye, kandi ubu buryo bushobora gukoreshwa mu gukemura ahantu handuye n’ibyuma biremereye.
MT hamwe no kurwanya imirasire
Imirasire ya Ionizing irashobora kubyara ubwinshi bwa radicals yubusa, ishobora kwangiza ibinyabuzima mu buryo butaziguye cyangwa butaziguye. Ubushakashatsi bwerekanye ko ubuyobozi bwo mu kanwa bwa MT bushobora kongera igihe cyo kubaho kwimbeba zanduye imishwarara imwe rukumbi ya ionizing imirasire, kandi bikagabanya kwangirika kwimikorere yumubiri iterwa numwanya umwe mwinshi hamwe nimirasire mike ya ionizing . MT yo mu kanwa irashobora gukuramo Cys nyinshi yinjira mumubiri. Itanga ibikoresho fatizo byo gusana imiyoboro ya disulfide yamenetse nimirase mumubiri.
Indwara ya MT na Parkison (PD)
Ubushakashatsi bwinshi bwerekanye ko MT igira ingaruka zo kurinda sisitemu y'imitsi. Ubushakashatsi bwerekanye ko mu mbeba za transgenji, gukabya gukabije kwa MT-1 bishobora guhindura ibimenyetso bya encephalite kandi bigatera gusana ubwonko. Nibintu birinda ingirabuzimafatizo. Binyuze mu bushakashatsi bwakozwe ku buryo bwo gutera imbeba na moderi ya ischemia, usanga MT-3 igira uruhare mu gusana ibyangiritse bya sisitemu yo hagati. Indwara ya PD iterwa no kwinjiza radicals yubusa na 6-hydroxydopamine, hamwe na zimwe mu zitera isoforms ya MT mu bwonko, nka stress ya okiside, cytokine hamwe nuburyo bwo gutwika ibintu, birashobora gukumira iyi neurotoxicity, itarimo MT yo gukuraho MT ifitanye isano.
Porogaramu
Metallothionein (MT) ni ubwoko bwa poroteyine nkeya ikungahaye kuri sisitemu n'icyuma. Bitewe nubushobozi bwayo bwo guhuza umubare munini wibyuma bya ion hamwe nibikorwa byihariye bya physiologique, byitabweho cyane mubijyanye na biohimiki. Amateka yubushakashatsi bwa MT amaze imyaka irenga 40, kandi ubushakashatsi ku miterere, imiterere, imiterere ya gene n'imikorere y'ibinyabuzima bwagiye bwimbitse. Ibyifuzo byo gusaba MT ni binini cyane, harimo ariko ntibigarukira kuri:
1. Urwego rwubuvuzi : MT ikoreshwa cyane mubuvuzi bwindwara zifata umutima nimiyoboro yubwonko nubwonko, ariko ntabwo byakoreshejwe mugicuri.
2. Ubuzima bwibiryo hamwe ninyongeramusaruro : MT irashobora gukoreshwa nkinyongera mubiribwa, inyongeramusaruro yubuzima no kwisiga kugirango itange inyungu zubuzima.
3. Ubwubatsi bwa genetike reagent : Muri injeniyeri yubuzima, MT ikoreshwa nka reagent kugirango iteze imbere ubushakashatsi nogukoresha injeniyeri.
4. Kurengera imiti n’ibidukikije : MT nayo ikoreshwa mubice byo kurengera imiti n’ibidukikije, urugero kugirango ikureho ibyuma byangiza.
Ingingo za laboratoire yubuhinzi : MT irashobora gukoreshwa nkingingo yubushakashatsi mubushakashatsi bwubuhinzi, cyane cyane mubushakashatsi bwanduye ry’ibyuma biremereye no kwihanganira ibimera byuma.
5. Byongeye kandi, MT ifite kandi inshingano zo kugira uruhare mu kubika, gutwara no guhinduranya ibintu bya sisitemu zinc n'umuringa, kwangiza ibintu biremereye byitwa cadmium, mercure na gurş, kurwanya imishwarara ya ionizing no gukuraho amatsinda yubusa ya hydroxyl. Ingirabuzima fatizo za MT zashyizwe mu itabi, petunia no mu bindi bimera hakoreshejwe ubwubatsi bwa geneti, kandi ibimera bya transgenji byagaragaje ko birwanya cyane umwanda wa kadmium. Niba gene ya MT yimuriwe muri clover na duckweed hanyuma igaterwa mu butaka cyangwa amazi yandujwe na kadmium na mercure, irashobora kwinjiza umubare munini w’uburozi bw’ubumara mu butaka n’amazi, kandi ikagira uruhare mu gukuraho ibyuma byangiza .
Ibicuruzwa bifitanye isano:
Uruganda rushya kandi rutanga aside Amino kuburyo bukurikira:
Gupakira & Gutanga
