●Berberine ni iki?
Berberine ni alkaloide isanzwe ikurwa mu mizi, ibiti n'ibishishwa by'ibimera bitandukanye, nka Coptis chinensis, Phellodendron amurense na Berberis vulgaris. Nibyingenzi byingenzi bigize Coptis chinensis kugirango igire ingaruka za antibacterial.
Berberine ni urushinge rwumuhondo rumeze nka kirisiti ifite uburyohe bukaze. Ikintu nyamukuru gikaze muri Coptis chinensis ni berberine hydrochloride. Iyi alkaloide ya isoquinoline ikwirakwizwa mubyatsi bitandukanye. Ibaho muri Coptis chinensis muburyo bwa hydrochloride (berberine hydrochloride). Ubushakashatsi bwerekanye ko iyi nteruro ishobora gukoreshwa mu kuvura ibibyimba, hepatite, indwara zifata umutima-mitsi, hypertension, inflammation, bagiteri na virusi, impiswi, indwara ya Alzheimer na artite.
Ni izihe nyungu z'ubuzima bwa Berberine?
1.Antioxidant
Mubihe bisanzwe, umubiri wumuntu ukomeza kuringaniza antioxydants na porokiside. Guhangayikishwa na Oxidative ni inzira yangiza ishobora kuba umuhuza wingenzi wangiza ingirabuzimafatizo, bityo bigatuma habaho indwara zitandukanye nkindwara zifata umutima, kanseri, indwara zifata ubwonko na diyabete. Umusaruro mwinshi wubwoko bwa ogisijeni (ROS), cyane cyane binyuze mukubyutsa gukabije kwa NADPH na cytokine cyangwa binyuze mumurongo wa transport ya mitochondrial electronique na okiside ya xanthine, bishobora gutera guhagarika umutima. Ubushakashatsi bwerekanye ko metabolite ya berberine na berberine byerekana ibikorwa byiza -OH byo guswera, ibyo bikaba bihwanye na vitamine C. ikomeye ya antioxydeant C. Ubuyobozi bwa berberine nimbeba za diyabete bushobora gukurikirana iyongerekana ryibikorwa bya SOD (superoxide dismutase) no kugabanuka kwa MDA (a ikimenyetso cya lipide peroxidation) urwego [1]. Ibindi bisubizo byerekana ko ibikorwa byo gusiba berberine bifitanye isano rya bugufi nigikorwa cyayo cya ferrous ion, kandi C-9 hydroxyl groupe ya berberine nigice cyingenzi.
2.Ibyimba
Habayeho raporo nyinshi ku ngaruka zo kurwanya kanseri yaberberine. Ubushakashatsi butandukanye bwakozwe mu myaka yashize bwerekanye ko berberine ifite akamaro kanini mu kuvura indwara zikomeye za kanseri nka kanseri y'intanga ngore, kanseri y'inkondo y'umura, kanseri y'inkondo y'umura, kanseri y'ibere, kanseri y'ibihaha, kanseri y'amara, kanseri y'impyiko, kanseri y'uruhago, na kanseri ya prostate. [2]. Berberine irashobora kubuza ikwirakwizwa ry'uturemangingo twibibyimba dukorana nintego zitandukanye. Irashobora guhindura imvugo ya oncogène na kanseri ifitanye isano na kanseri kugirango igere ku ntego yo kugenzura ibikorwa byimisemburo ifitanye isano kugirango ibuze ikwirakwizwa.
3.Gabanya Lipide Yamaraso no Kurinda Sisitemu Yumutima
Berberine igira uruhare runini mu kuvura indwara z'umutima n'imitsi kandi ifite uburyo bwinshi bwo kuyikoresha. Berberine igera ku ntego yo kurwanya arththmia mu kugabanya ibyago byo gukubitwa imburagihe hakiri kare no kubuza ko tachycardia ibaho. Icya kabiri, dyslipidemiya nimpamvu nyamukuru itera indwara yumutima nimiyoboro y'amaraso, irangwa no kuzamuka kwa cholesterol yuzuye, triglyceride, hamwe na cholesterol ya lipoprotein nkeya (LDL), no kugabanuka kwa lipoprotein (HDL), kandi berberine irashobora gukomeza cyane ituze ry'ibi bipimo. Indwara ndende ya hyperlipidemiya nimpamvu ikomeye itera plaque ya atherosklerotike. Biravugwa ko berberine ifata reseptor ya LDL muri hepatocytes kugirango igabanye urugero rwa cholesterol ya muntu muri hepatocytes. Ntabwo aribyo gusa,berberineifite ingaruka nziza ya inotropique kandi yakoreshejwe mukuvura kunanirwa k'umutima.
4.Gabanya Isukari Yamaraso kandi igenga Endocrine
Indwara ya Diyabete (DM) ni indwara ya metabolike irangwa no kwiyongera k'isukari mu maraso (hyperglycemia) iterwa no kuba selile pancreatic B idashobora gukora insuline ihagije, cyangwa gutakaza insimburangingo zifatika zifata insuline. Ingaruka ya hypoglycemic ya berberine yavumbuwe ku buryo butunguranye mu myaka ya za 1980 mu kuvura abarwayi ba diyabete barwaye impiswi.
Ubushakashatsi bwinshi bwerekanye koberberineigabanya isukari mu maraso ikoresheje uburyo bukurikira:
Izibuza okiside ya glucose mitochondrial kandi itera glycolysis, hanyuma ikongera glucose metabolism;
Kugabanya urwego rwa ATP muguhagarika imikorere ya mitochondial mu mwijima;
Kubuza ibikorwa bya DPP 4 (protease ya serine iboneka hose), bityo igahindura peptide zimwe na zimwe zigira uruhare mu kongera urugero rwa insuline imbere ya hyperglycemia.
Ber Berberine igira ingaruka nziza mukuzamura insuline no gukoresha glucose mu myenda igabanya lipide (cyane cyane triglyceride) hamwe na aside irike ya plasma yubusa.
Incamake
Muri iki gihe,berberineBirashobora guhuzwa muburyo bwa artificiel kandi bigahinduka muburyo bwa kristu yubuhanga. Ifite igiciro gito kandi n'ikoranabuhanga rigezweho. Hamwe niterambere ryubushakashatsi bwubuvuzi hamwe nubushakashatsi bwimbitse, berberine izerekana ingaruka zubuvuzi. Ku ruhande rumwe, berberine ntabwo yageze ku musaruro udasanzwe gusa mu bushakashatsi bwa farumasi gakondo muri antibacterial, antiviral, anti-inflammatory, anti-tumor, anti-diabete, no kuvura indwara zifata umutima-mitsi n’ubwonko, ahubwo yanashizeho uburyo bwa tekinoroji ya kirisitu hamwe nisesengura rya morfologiya. byitabweho cyane. Bitewe nubushobozi bukomeye hamwe nuburozi buke ningaruka mbi, bifite amahirwe menshi mugukoresha amavuriro kandi bifite ibyerekezo byinshi. Hamwe niterambere ryibinyabuzima bigize selile, uburyo bwa farumasi ya berberine buzasobanurwa kuva kurwego rwa selile ndetse no murwego rwa molekile hamwe nintego, bizatanga ishingiro ryukuri kubikorwa byubuvuzi.
● NEWGREEN IsokoBerberine/ Ifu ya Liposomal Berberine / Capsules / Ibinini
Igihe cyo kohereza: Ukwakira-28-2024
