Mugihe tugenda dusaza, imikorere yingingo zabantu igenda yangirika buhoro buhoro, ibyo bikaba bifitanye isano rya bugufi no kwiyongera kwindwara zifata ubwonko. Imikorere mibi ya mitochondrial ifatwa nkimwe mubintu byingenzi muriki gikorwa. Vuba aha, itsinda ry’ubushakashatsi bwa Ajay Kumar wo mu kigo cy’Ubuhinde gishinzwe ubuvuzi gakondo bw’Abashinwa n’Uburengerazuba bw’ubuvuzi bwasohoye ibisubizo by’ubushakashatsi muri ACS Pharmacology & Translational Science, byerekana uburyo bwakoreshwa.ingonabidindiza gusaza ubwonko numubiri mugutezimbere ingufu za selile.
Mitochondria ni "inganda zingufu" mu ngirabuzimafatizo, zishinzwe kubyara ingufu nyinshi zisabwa na selile. Hamwe n'imyaka, kugabanuka kw'imikorere y'ibihaha, kubura amaraso, hamwe n'indwara ziterwa na microcirculatory bitera okisijene idahagije ku mitsi, bigatera hypoxia idakira ndetse bikanongera imikorere mibi ya mitochondial, bityo bigatuma iterambere ry’indwara zifata ubwonko. Crocetin nikintu gisanzwe gifite ubushobozi bwo kunoza imikorere ya mito-iyambere. Ubu bushakashatsi bugamije kumenya ingaruka za crocetine ku mikorere ya mitochondial ku mbeba zashaje n'ingaruka zayo zo kurwanya gusaza.
● NikiCrocetin?
Crocetin ni aside isanzwe ya apocarotenoid dicarboxylic iboneka mu ndabyo ya crocus hamwe na glycoside, crocetin, n'imbuto za Gardenia jasminoides. Bizwi kandi nka acide crocetic. [3] [4] Ikora amatafari atukura ya kirisita itukura hamwe na 285 ° C.
Imiterere yimiti ya crocetine ikora intandaro yo hagati ya crocetine, uruganda rushinzwe ibara rya saffron. Ubusanzwe Crocetin ikurwa mubucuruzi mu mbuto za gardenia, kubera igiciro kinini cya saffron.
● Bikora guteCrocetinKongera ingufu za selile?
Abashakashatsi bakoresheje imbeba za C57BL / 6J. Imbeba zishaje zagabanyijwemo amatsinda abiri, itsinda rimwe ryakira imiti ya crocetine amezi ane, irindi tsinda rikora nk'itsinda rishinzwe kugenzura. Ubushobozi bwo kumenya no gutwara moteri yimbeba bwasuzumwe nubushakashatsi bwimyitwarire nko gupima umwanya wibibanza no gupima umurima, kandi uburyo bwibikorwa bya crocetin bwasesenguwe nubushakashatsi bwa farumasi hamwe nuburyo bukurikirana. Isesengura ryinshi ryisubiramo ryakoreshejwe muguhindura ibintu bitera urujijo nkimyaka nuburinganire kugirango harebwe ingaruka za crocetine kumikorere ya moteri na moteri yimbeba.
Ibisubizo byagaragaje ko nyuma y'amezi ane yaingonakuvura, imyitwarire yo kwibuka hamwe nubushobozi bwa moteri yimbeba byatejwe imbere cyane. Itsinda rivura ryitwaye neza mu kizamini cyo kwibuka, kandi cyafashe igihe gito cyo kubona ibiryo, kiguma mu kuboko kurigata igihe kirekire, kandi kigabanya inshuro binjiye mu kuboko kutarigita ku ikosa. Mu kizamini cyo gufungura ikibuga, imbeba zo mu itsinda ryavuwe na crocetin zarakoraga cyane, kandi zimura intera n'umuvuduko.
Mugukurikirana inyandiko-mvugo yose yimbeba ya hippocampus, abashakashatsi basanze ibyoingonaubuvuzi bwateje impinduka zikomeye mumagambo ya gene, harimo no kugenzura imiterere ya genes zifitanye isano nka BDNF (ibintu biva mu bwonko biva mu bwonko).
Ubushakashatsi bwa Pharmacokinetic bwerekanye ko crocetine ifite imbaraga nke mu bwonko kandi nta kwirundanya, byerekana ko ari umutekano muke. crocetin yazamuye imikorere ya mitochondial kandi yongera ingufu za selile mu mbeba zishaje zongera ikwirakwizwa rya ogisijeni. Kunoza imikorere ya mitochondrial bifasha gutinda gusaza kwubwonko numubiri no kongera igihe cyimbeba.
Ubu bushakashatsi bwerekana koingonaIrashobora gutinza cyane ubwonko numubiri gusaza kandi ikongerera igihe cyimbeba zishaje mugutezimbere imikorere ya mito-iyambere no kongera ingufu za selile. Ibyifuzo byihariye nibi bikurikira:
Ongeraho crocetin mu rugero: Kubantu bakuze, kuzuza crocetine mu rugero birashobora gufasha kunoza ubushobozi bwubwenge na moteri no gutinda gusaza.
Gucunga neza ubuzima: Usibye kuzuza crocetine, ugomba no gukomeza indyo yuzuye, imyitozo ngororamubiri isanzwe hamwe nubuziranenge bwibitotsi kugirango uteze imbere ubuzima rusange.
Witondere umutekano: Nubwoingonayerekana umutekano mwiza, uracyakeneye kwitondera dosiye mugihe wuzuza kandi ukabikora uyobowe na muganga cyangwa inzobere mu mirire.
● NEWGREEN Gutanga Crocetin / Crocin / Ibikomoka kuri Saffron
Igihe cyo kohereza: Ukwakira-23-2024
