Mu myaka yashize,NMN, imaze kumenyekana kwisi yose, yakoresheje ubushakashatsi bwinshi. Ni bangahe uzi kuri NMN? Uyu munsi, tuzibanda ku kumenyekanisha NMN, ikundwa na bose.
● NikiNMN?
NMN yitwa β-Nicotinamide Mononucleotide, cyangwa NMN mugihe gito. NMN ifite diastereomers ebyiri: α na β. Ubushakashatsi bwerekanye ko β-ubwoko bwa NMN gusa bufite ibikorwa byibinyabuzima. Mu buryo bwubaka, molekile igizwe na nikotinamide, ribose, na fosifate.
NMN nimwe mubibanziriza NAD +. Muyandi magambo, ingaruka yibanze ya NMN igerwaho binyuze muguhindura NAD +. Mugihe tugenda dusaza, urwego rwa NAD + mumubiri wumuntu rugenda rugabanuka.
Mu cyegeranyo cy’ubushakashatsi bw’ibinyabuzima byo mu mwaka wa 2018, incamake ebyiri z’ibanze zo gusaza kwabantu:
1. Ibyangiritse biterwa na stress ya okiside (ibimenyetso bigaragara nkindwara zitandukanye)
2. Kugabanuka kurwego rwa NAD + muri selile
Umubare munini wibyagezweho mumasomo mubushakashatsi bwa NAD + bwo kurwanya gusaza byakozwe nabashakashatsi bakomeye ku isi bashyigikira umwanzuro ko kongera urwego rwa NAD + bishobora kuzamura ubuzima bwiza muri byinshi kandi bigatinda gusaza.
● Ni izihe nyungu z'ubuzima zaNMN?
1.Kongera NAD + ibirimo
NAD + ni ikintu cyingenzi cyo gukomeza imikorere yumubiri. Iba mu ngirabuzimafatizo zose kandi igira uruhare mu bihumbi ibihumbi byumubiri. Imisemburo irenga 500 mumubiri wumuntu isaba NAD +.
Duhereye ku gishushanyo, dushobora kubona ko inyungu zo kuzuza NAD + mu ngingo zitandukanye zirimo kuzamura ubuzima bwubwonko nubwonko bwimitsi, umwijima nimpyiko, imiyoboro yamaraso, umutima, tissue lymphatique, imyanya myororokere, pancreas, tipusi ya adipose, n'imitsi.
Mu mwaka wa 2013, itsinda ry’ubushakashatsi riyobowe na Porofeseri David Sinclair wo mu Ishuri Rikuru ry’Ubuvuzi rya Harvard ryerekanye binyuze mu bushakashatsi ko nyuma y’ubuyobozi bwa NMN bwo mu kanwa icyumweru kimwe, urwego rwa NAD + mu mbeba z’amezi 22 rwiyongereye, kandi n’ibimenyetso by’ibanze bya biohimiki bijyanye na mitochondrial homeostasis na imikorere yimitsi yagaruwe kumiterere yimbeba zikiri nto zingana namezi 6.
2. Koresha poroteyine za SIR
Ubushakashatsi bwakozwe mu myaka 20 ishize bwerekanye ko Sirtuins igira uruhare runini mu mikorere ya selile hafi ya yose, bigira ingaruka ku mikorere ya physiologique nko gutwika, gukura kw ingirabuzimafatizo, injyana ya sikadiyani, imbaraga za metabolisme, imikorere ya neuronal no kurwanya imihangayiko.
Sirtuins bakunze kwita umuryango wa proteine uramba, akaba umuryango wa NAD + -bishingiye kuri proteine deacetylase.
Muri 2019, Porofeseri Kane AE wo mu ishami rya genetika mu ishuri ry'ubuvuzi rya Harvard n'abandi bavumbuye koNMNni intangiriro yingenzi kuri synthesis ya NAD + mumubiri. NMN imaze kongera urwego rwa NAD + muri selile, ingaruka nyinshi zayo zingirakamaro (nko kunoza metabolisme, kurinda sisitemu yumutima nimiyoboro, nibindi) bigerwaho mugukora Sirtuins.
3. Gusana ibyangiritse kuri ADN
usibye kugira ingaruka kumikorere ya Sirtuins, urwego rwa NAD + mumubiri nabwo ni substrate yingenzi ya ADN yo gusana enzyme PARPs (poly ADP-ribose polymerase).
4. Guteza imbere metabolism
Metabolism ni ikusanyirizo ryimiti ikomeza ubuzima mubinyabuzima, ibemerera gukura no kubyara, kubungabunga imiterere, no gusubiza ibidukikije. Metabolism ni inzira ibinyabuzima bikomeza guhana ibintu n'ingufu. Iyo bimaze guhagarara, ubuzima bwibinyabuzima buzarangira. Porofeseri Anthony wo muri kaminuza ya Californiya hamwe nitsinda rye basanze NAD + metabolism yarabaye umuti ushobora kuvura indwara ziterwa no gusaza no kwagura ubuzima bwabantu no kubaho.
5. Guteza imbere imiyoboro y'amaraso kuvugurura no gukomeza imiyoboro y'amaraso
Imiyoboro yamaraso ningingo zingenzi zo gutwara ogisijeni nintungamubiri, gutunganya dioxyde de carbone na metabolite, no kugenzura ubushyuhe bwumubiri. Mugihe tugenda dusaza, imiyoboro y'amaraso itakaza buhoro buhoro guhinduka, gukomera, kubyimbye, no kugabanuka, bitera "arteriosclerose."
Mu mwaka wa 2020, ubushakashatsi bwakozwe na bamwe mu banyeshuri ba PhD bo muri kaminuza y’ikoranabuhanga ya Zhejiang mu Bushinwa, harimo na Sh, bwerekanye ko nyuma y’ubuyobozi bwo mu kanwa bwaNMNku mbeba zihebye, ibimenyetso byo kwiheba byagabanutse mu kongera urwego rwa NAD +, gukora Sirtuin 3, no kunoza ingufu za mitochondial metabolism muri hippocampus na selile yumwijima yubwonko bwimbeba.
6. Kurinda ubuzima bwumutima
Umutima ningingo zingenzi mumubiri wumuntu kandi ni ngombwa mugukomeza imikorere yumutima. Kugabanuka kurwego rwa NAD + bifitanye isano no gutera indwara zitandukanye zifata umutima. Umubare munini wubushakashatsi bwibanze bwerekanye kandi ko kuzuza coenzyme nshobora kugirira akamaro indwara zumutima.
7. Komeza ubuzima bwubwonko
Imikorere mibi ya neurovasculaire irashobora gutera imitsi hakiri kare na neurodegenerative cognitive kwangirika. Kubungabunga imikorere y'amaraso ni ngombwa mu gukumira indwara zifata ubwonko.
Impamvu zishobora gutera nka diyabete, hypertension yo hagati, umubyibuho ukabije wo hagati, kudakora kumubiri no kunywa itabi byose bifitanye isano no guta umutwe hamwe n'indwara ya Alzheimer.
8. Kunoza insuline
Gukenera insuline bisobanura urwego rwo kurwanya insuline. Hasi ya insuline igabanuka, niko igabanuka ryisukari.
Kurwanya insuline bivuga kugabanuka kwimyumvire yingingo zigenewe insuline kubikorwa bya insuline, ni ukuvuga leta aho igipimo gisanzwe cya insuline gitanga ingaruka zidasanzwe zisanzwe z’ibinyabuzima. Impamvu nyamukuru itera diyabete yo mu bwoko bwa 2 ni insuline nkeya hamwe na insuline nkeya.
NMN, nk'inyongera, irashobora gufasha kunoza insuline mukongera urwego rwa NAD +, kugenzura inzira za metabolike, no kunoza imikorere ya mito-iyambere.
9. Fasha mugucunga ibiro
Ibiro ntibigira ingaruka gusa kubuzima nubuzima, ahubwo biba imbarutso yizindi ndwara zidakira. Ubushakashatsi bwerekanye ko NAD precursor β-nicotinamide mononucleotide (NMN) ishobora guhindura zimwe mu ngaruka mbi ziterwa nimirire yuzuye amavuta (HFD).
Muri 2017, Porofeseri David Sinclair wo mu Ishuri Rikuru ry’Ubuvuzi rya Harvard hamwe n’itsinda ry’ubushakashatsi bo mu Ishuri Rikuru ry’Ubuvuzi rya Ositaraliya bagereranije imbeba z’abagore bafite umubyibuho ukabije bakoze imyitozo ku byumweru 9 cyangwa batewe inshinge na NMN buri munsi mu minsi 18. Ibisubizo byerekanaga ko NMN isa nkaho igira ingaruka zikomeye kuri metabolisme yumwijima na synthesis kuruta gukora siporo.
Umutekano waNMN
NMN ifatwa nkumutekano mubushakashatsi bwinyamaswa, kandi ibisubizo birashimishije. Ibigeragezo 19 byamavuriro byabantu byatangiye, muri byo 2 byatangaje ibisubizo byubushakashatsi.
Itsinda ry’ubushakashatsi ryaturutse mu ishuri ry’ubuvuzi rya kaminuza ya Washington i St. Louis ryasohoye inkuru mu kinyamakuru cyo hejuru cy’ubumenyi "Science", kigaragaza ibyavuye mu igeragezwa rya mbere ry’amavuriro y’abantu ku isi, ryemeza inyungu za metabolike ya NMN ku mubiri w’umuntu.
● NEWGREEN Gutanga ifu ya NMN / Capsules / Liposomal NMN
Igihe cyo kohereza: Ukwakira-15-2024
