• NikiTetrahydrocurcumin ?
Rhizoma Curcumae Longae ni rhizoma yumye ya Curcumae Longae L. Ikoreshwa cyane nk'ibara ry'ibiryo n'impumuro nziza. Ibigize imiti birimo ahanini curcumin namavuta ahindagurika, usibye sakaride na steroli. Curcumin (CUR), nka polifenol karemano mu gihingwa cya curcuma, byagaragaye ko ifite ingaruka zitandukanye za farumasi, zirimo anti-inflammatory, antioxidant, ogisijeni ikuraho burundu, kurinda umwijima, kurwanya fibrosis, ibikorwa byo kurwanya ibibyimba no kwirinda y'indwara ya Alzheimer (AD).
Curcumin ihinduranya vuba mumubiri muri conjugate ya glucuronic, acide sulfurike conjugate, dihydrocurcumin, tetrahydrocurcumin, na hexahydrocurcumin, nayo ihinduka tetrahydrocurcumin. Ubushakashatsi bwakorewe ubushakashatsi bwemeje ko curcumin ifite umutekano muke (reba Photodecomposition), kutagira amazi meza hamwe na bioavailable nke. Kubwibyo, ibyingenzi byingenzi bigize metabolike tetrahydrocurcumin mumubiri byahindutse ahantu h’ubushakashatsi mu gihugu ndetse no hanze yarwo mumyaka yashize.
Tetrahydrocurcumin. Inzira ya molekile ni C21H26O6, uburemere bwa molekile ni 372.2, ubucucike ni 1.222, naho gushonga ni 95 ℃ -97 ℃.
• Ni izihe nyunguTetrahydrocurcuminMu Kuvura Uruhu?
1. Ingaruka ku musaruro wa melanin
Tetrahydrocurcumin irashobora kugabanya ibirimo melanin muri selile B16F10. Iyo itangwa rya tetrahydrocurcumin (25, 50, 100, 200μmol / L) ryatanzwe, melanine yagabanutse kuva 100% igera kuri 74.34%, 80.14%, 34.37%, 21.40%.
Tetrahydrocurcumin irashobora guhagarika ibikorwa bya tyrosinase muri selile B16F10. Iyo ubunini bwa tetrahydrocurcumin (100 na 200μmol / L) bwahawe ingirabuzimafatizo, ibikorwa bya tyrosinase yo mu nda byagabanutse kugera kuri 84.51% na 83.38%.
2. Kurwanya gufotora
Nyamuneka reba igishushanyo cyimbeba hepfo: Ctrl (kugenzura), UV (UVA + UVB), THC (UVA + UVB + THC THC100 mg / kg, yashonga muri 0,5% sodium carboxymethyl selulose). Amafoto yuruhu inyuma yimbeba za KM mugihe cyibyumweru 10 nyuma yo kuvura THC yagenwe no kurasa UVA. Amatsinda atandukanye afite imirasire ya UVA ihwanye no gusaza kworoheje yasuzumwe n amanota ya Bissett. Indangagaciro zatanzwe ni uburyo bwo gutandukana (N = 12 / itsinda). * P <0.05, ** P.
Uhereye kubigaragara, ugereranije nitsinda risanzwe rishinzwe kugenzura, uruhu rwitsinda rishinzwe kugenzura icyitegererezo rwari rukaze, rugaragara erythma, ibisebe, iminkanyari yimbitse kandi yijimye, iherekejwe nimpinduka zisa nimpu, byerekana ibintu bisanzwe bifotora. Ugereranije nicyitegererezo cyo kugenzura itsinda, ibyangiritse urwego rwatetrahydrocurcuminItsinda rya mg / kg 100 ryaragabanutse cyane ugereranije n’itsinda rishinzwe kugenzura icyitegererezo, kandi nta gisebe na erythma byabonetse ku ruhu, gusa pigmentation nkeya n’iminkanyari nziza byagaragaye.
3. Antioxydants
Tetrahydrocurcumin irashobora kongera urwego rwa SOD, kugabanya urwego rwa LDH no kongera urwego rwa GSH-PX muri selile HaCaT.
Gusiba DPPH radicals yubusa
Uwitekatetrahydrocurcuminigisubizo cyakuweho inshuro 10, 50, 80, 100, 200, 400, 800, 1600 inshuro zikurikiranye, kandi igisubizo cyicyitegererezo cyavanze neza na 0.1mmol / L DPPH igisubizo ku kigereranyo cya 1: 5. Nyuma yo kwitwara mubushyuhe bwicyumba cya 30min, agaciro ko kwinjiza kugenwa kuri 517nm. Ibisubizo byerekanwe ku gishushanyo:
4. Irinde gutwika uruhu
Ubushakashatsi bwakozwe bwerekanye ko gukira ibikomere byimbeba byagaragaye ubudahwema iminsi 14, mugihe geli ya THC-SLNS yakoreshejwe, umuvuduko wo gukira ibikomere ningaruka za THC no kugenzura neza byihuse kandi byiza, gahunda yo kumanuka yari gel THC-SLNS gel >
THC> Igenzura ryiza.
Hano hepfo amashusho yerekana ishusho yimbeba yakomeretse hamwe nubushakashatsi bwa histopathologique, A1 na A6 yerekana uruhu rusanzwe, A2 na A7 yerekana gel ya THC SLN gel, A3 na A8 yerekana igenzura ryiza, A4 na A9 yerekana gel ya THC, na A5 na A10 yerekana ubusa bukomeye lipid nanoparticles (SLN), kimwe.
• Gushyira mu bikorwaTetrahydrocurcuminKwisiga
1.Ibicuruzwa byita ku ruhu:
Ibicuruzwa birwanya gusaza:Ikoreshwa mumavuta yo kurwanya gusaza hamwe na serumu kugirango ifashe kugabanya iminkanyari n'imirongo myiza no kunoza uruhu rworoshye.
Ibicuruzwa byera:Wongeyeho kwera hamwe na cream kugirango bifashe kunoza imiterere yuruhu hamwe nibibara.
2.Anti-inflammatory ibicuruzwa:
Ikoreshwa mubicuruzwa byita ku ruhu byoroshye nko guhumuriza no gusana amavuta kugirango ugabanye umutuku no kurakara.
3.Gusukura ibicuruzwa:
Ongeraho isuku na exfoliants kugirango ufashe kweza uruhu no gutanga inyungu za antibacterial kugirango wirinde acne.
4.Ibicuruzwa byerekana izuba:
Ikora nka antioxydeant kugirango yongere imbaraga zizuba ryizuba kandi irinde uruhu imirasire ya UV.
5. Mask ya Face:
Ikoreshwa mumasike atandukanye yo mumaso kugirango itange ibyokurya byimbitse kandi bisanwe, bitezimbere uruhu.
Tetrahydrocurcuminikoreshwa cyane mu kwisiga, gutwikira uruhu, gusukura, kurinda izuba nizindi nzego. Itoneshwa na antioxydeant, anti-inflammatory and whiteing.
Igihe cyo kohereza: Ukwakira-10-2024
